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Preclinical research indicates that NNMT inhibition may influence adipose tissue function, mitochondrial efficiency, and intracellular energy utilization through mechanisms distinct from traditional endocrine or appetite-regulating pathways
Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and diabetic peripheral neuropathy Nature article: Shows prolonged metformin use correlates with lower B12 and more severe diabetic neuropathy
These side effects are typically minor and short-lived
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